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At last managed depress reproduction process of human immunodeficiency virus

At last managed depress reproduction process of human immunodeficiency virusResearchers from Cambridge University and King's College London managed to depress reproduction of AIDS by blocking the holes in the protein shell.

These microscopic pore structure used for infectious virus DNA. The results of research biologists presented in an article published in the journal Nature.

AIDS belongs to the retrovirus. To infect a cell, it must convert RNA that make up its genome into the DNA. But scientists did not know how the virus gets the necessary nucleotides - the building blocks of genetic material. It was also unclear how AIDS manages to protect its DNA identification of protective systems of the cell.

The researchers studied the molecular structure of the capsid - the outer shell of the virus, which consists of proteins. In addition, virologists have created a mutant version of AIDS, to understand how changes in the capsid affect its ability to infection. It turned out that there are special membrane pores, whose shape resembles a diaphragm. Through them fall into nucleotides, while the other molecules, including those responsible for the recognition of foreign DNA, remain outside. When scientists blocked pores heksakarboksybenzola, the virus lost its ability to samokopyuvannya.

The authors stressed that they tested the inhibitor can not penetrate into the cell through the plasma membrane. However, they hope that in the future will be able to solve this problem and create effective drugs against AIDS. The virus in this case can not proliferate and inhibit the activity of the immune system, which helps prevent the development of AIDS infected.
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